May 3, 2016

42716PoplackandPizzo640The 12th Annual Texas Children’s Cancer and Hematology Centers Research Symposium on April 7 offered faculty and trainees the opportunity to present their latest research and reunited the editors of the leading textbook on pediatric oncology.

The 7th edition of “Principles and Practice of Pediatric Oncology” is co-edited by Dr. David Poplack, professor of pediatrics at Baylor and director of Texas Children’s Cancer and Hematology Centers, and Dr. Philip Pizzo, former dean of the Stanford University School of Medicine and founding director of the Stanford Distinguished Careers Institute.

Pizzo, whose career focus has been on the treatment of childhood cancer and infectious complications in children whose immune systems are compromised by diseases such as cancer and AIDS, was the keynote speaker at the symposium’s morning session. He offered a reflection on his career and participated in a question-and-answer session moderated by Poplack.

Dr. Peggy Goodell, professor of pediatrics at Baylor and part of the Center for Cell and Gene Therapy, delivered the afternoon keynote. The symposium also included a dozen oral research presentations and many more poster presentations.

Oral Presentation Winners:

1st place: Ifigeneia Tzannou, instructor, Center for Cell and Gene Therapy
Administration of most closely HLA-matched multivirus-specific T cells for the treatment of EBV, CMV, AdV, HHV-6 and BKV post allogeneic hematopoietic stem cell transplant

2nd place: Jacob Junco, postdoctoral associate in pediatric oncology
Leukemogenesis in down syndrome acute lymphoblastic leukemia

3rd place: Frank Lin, assistant professor of pediatrics – oncology
Diagnostically and therapeutically relevant alterations in rare pediatric CNS tumors revealed by integrated sequencing

Poster Presentation Winners:

1st place: Paibel Aguayo-Hiraldo, clinical postdoctoral fellow in pediatric hematology/oncology
Adoptive T cell therapy for the prevention and treatment of parainfluenza virus 3 infections post allogeneic hematopoietic stem cell transplant

2nd place: Vijetha Kumar, research assistant in pathology
Clinical validation of a next-generation target RNA sequencing assay for detection of fusion genes in pediatric and solid tumors

3rd place: Arpad Szoor, postdoctoral associate in the Center for Cell and Gene Therapy
T cell activating mesenchymal stem cells as a biotherapeutic for HCC

March 15, 2016

31616KristinaWilson175Kristina Wilson, a senior speech-language pathologist and clinical researcher on the Cleft Palate Team at Texas Children’s Hospital, was recently elected to the Executive Council of the American Cleft Palate-Craniofacial Association (ACPA), an international non-profit medical society of health care professionals who treat and/or perform research on oral cleft and craniofacial conditions.

In her role on the council, Wilson will help guide the 2,500-member organization in its efforts to foster communication and cooperation among professionals from all specialties involved in the treatment of children and adults with cleft lip, cleft palate, and craniofacial anomalies.

For more than 65 years, their goal has been to provide optimal care for this group of patients and their families. Because of the diverse needs of these patients, and the required services of many different specialists, interdisciplinary cooperation and team care is essential to the patients served.

Wilson has been providing such care for the past decade with the Cleft Palate Team at Texas Children’s Hospital. In addition to her role with the hospital, she holds a faculty appointment at Baylor College of Medicine in the Division of Plastic Surgery. She also is the assistant coordinator of the American Speech-Language-Hearing Association’s Special Interest Group 5 – Craniofacial and Velopharyngeal Disorders.

March 8, 2016

3416ChristianSchaaf175Dr. Christian Schaaf, assistant professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children’s, has been named the inaugural recipient of the Seldin-Smith Award for Pioneering Research.

The Seldin-Smith Award was established by the American Society for Clinical Investigation (ASCI) to recognize the most promising young physician-scientists in the country. One recipient will be chosen annually for this honor. Founded in 1908, ASCI is one of the oldest and most highly-respected medical honor societies for physician-scientists in the U.S.

“I am humbled to receive this prestigious award named after Drs. Donald W. Seldin and Lloyd H. ‘Holly’ Smith, heroes of academic medicine,” Schaaf said. “For the past 50 years, they’ve provided exemplary leadership in science, medicine and education. This award recognizes contributions to all three areas. For me, diligently pursuing patient care, science, and medical education has made my work profoundly meaningful.”

Schaaf, a medical geneticist who solves complex and challenging medical mysteries, combines astute clinical observations with meticulous basic research. His studies have led to important contributions in understanding the genetic basis of autism spectrum disorder and to the discovery of several genes for neurodevelopmental disorders and rare genetic syndromes. Two of these rare syndromes now bear his name: Bosch-Boonstra-Schaaf Optic Atrophy syndrome and Schaaf-Yang syndrome. Providing patients with an accurate diagnosis can be empowering. It ensures improved guidance, appropriate genetic counseling, and the ability to connect with similarly-affected families worldwide. These are important steps toward a better quality of life.

For the inaugural Seldin-Smith Award, ASCI sought nominations from outstanding physician-scientists who have demonstrated exceptional creativity and accomplishments in biomedical research. The selection committee comprised top luminaries in academic medicine, including four Nobel Laureates. Schaaf was chosen unanimously after a stringent two-step review of numerous nominations of exceptional early-stage physician-scientists from the U.S. and abroad.

Schaaf will be formally recognized at the ASCI dinner in Chicago on Friday, April 15. Drs. Seldin and Smith, as well as Schaaf’s mentor, NRI Director Dr. Huda Zoghbi, will be among the distinguished guests present at the ceremony.

In addition, Schaaf will receive an unrestricted grant of $30,000 to advance academic efforts, an invitation to deliver a research talk at the 2017 ASCI/AAP Joint Meeting and mentoring by the members of the Seldin-Smith Award Selection Committee and Advisory Committee.

March 1, 2016

8515Drzoghbi175Dr. Huda Zoghbi, known for her groundbreaking research on Rett syndrome and other neurological disorders, is the inaugural recipient of the Mechthild Esser Nemmers Prize in Medical Science at Northwestern University.

The Nemmers prize, which carries a $200,000 stipend, is awarded to a physician-scientist whose body of research exhibits outstanding achievement in their discipline as demonstrated by works of lasting significance. A jury of distinguished scientists from around the country made the final selection.

Zoghbi, a professor of pediatrics, molecular and human genetics, and neurology and neuroscience at Baylor College of Medicine and director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s, has devoted her career to uncovering the genetic roots of rare neurodegenerative and neurodevelopmental diseases that affect her patients.

“The Nemmers Prize in Medical Science recognizes an outstanding investigator whose discoveries have significantly contributed to improving human health beyond the individual patient,” said Dr. Eric Neilson, vice president for medical affairs and Lewis Landsberg Dean at Northwestern University Feinberg School of Medicine. “Huda is a superb physician-scientist who has transformed the way we think about the genetic determinants and mechanisms of diseases. We are privileged to honor her with this inaugural award and for her to share her work with us.”

In connection with this award, Zoghbi will deliver a public lecture and participate in other scholarly activities at Feinberg in the coming year.

“It is a tremendous honor to be the inaugural Nemmers Prize recipient in Medical Science, and to have the opportunity to share my research with the stellar community of Northwestern University. It is truly humbling to be rewarded for what I love to do,” Zoghbi said.

bench-and-beside-Header2 Bench and Bedside is a digest of the previous month’s stories about the clinical and academic activities of our physicians and scientists. We welcome your submissions and feedback.

February 2

Texas Children’s, Rice University team up to develop new way to repair birth defect

Bioengineers at Texas Children’s Hospital and Rice University have won a National Institutes of Health grant to develop a new generation of patches to repair the damaged hearts of infants. The $1.9 million, 5-year grant will allow Jeffrey Jacot and his team to take the next steps in a long-running drive to improve the survival rates of such infants, many of whom are diagnosed in utero and require surgery soon after birth.

February 2

Department of State Health Services to award Texas Children’s $1 million grant for SIU 3116SIUTraining300

Texas Children’s is set to receive a $1 million grant from the Texas Department of State Health Services (DSHS) to put toward its newly constructed Special Isolation Unit at Texas Children’s Hospital West Campus. The funds, to be delivered during the next five years, will specifically go toward Ebola preparedness activities that bolster employee safety and quality of care.

February 2

Texas Children’s convenes task force, urges employees to educate themselves on Zika

3116zikamosquito300In light of the multiple confirmed cases of Zika infection in Texas due to foreign travel, Texas Children’s leaders encourage employees, particularly pregnant women, to refrain from traveling to areas where the outbreak is growing and to follow precautionary measures to protect themselves from Zika exposure. Since the mosquito-carrying virus has been known to increase the risk of microcephaly, a neurological fetal birth defect, Texas Children’s recently convened a task force to develop management and research strategies based on screening criteria outlined by the Centers for Disease Control for pregnant women who may have been exposed to the Zika virus.

February 2 Kline: Children deserve access to best care

Many patients have been left scrambling to find a new medical home when a number of insurance companies decided not to provide in-network coverage for many hospitals in the Texas Medical Center, including Texas Children’s Hospital. Physician-in-Chief Dr. Mark W. Kline talks about how all children deserve access to the best care.

February 2

Zoghbi to receive medal for pioneering advancements in neuroscience research

3116zoghbilab300Dr. Huda Zoghbi, director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s, will receive the 2016 Jessie Stevenson Kovalenko Medal from the National Academy of Science in April for her achievements in neuroscience, which includes unlocking the genetic and molecular mysteries behind rare neurological disorders.

 

February 2

Clinical Research Center presents research award to Dr. Anvari

The Clinical Research Center will present the Clinical Research Award for First Quarter 2016 to Dr. Sara Anvari, physician, Allergy and Immunology. Dr. Anvari is a dedicated clinical scientist for the food allergy research trials at Texas Children’s Hospital.

February 9

Three NRI researchers recognized for their contributions to neuroscience research

Drs. Michael Wangler and Shinya Yamamoto recently obtained a research grant from the Simon’s Foundation for Autism Research Initiative (SFARI) to advance their study on autism spectrum disorders. Their study titled, “In vivo functional analysis of autism candidate genes” is one of five projects selected for research funding by the SFARI. Dr. Andrea Ballabio, founder and director of the Telethon Institute of Genetics and Medicine (TIGEM), Italy, professor at Baylor and faculty member at the NRI, has been selected to receive the 2016 Louis-Jeantet Prize for Medicine. He will share this award with biochemist John Diffley, associate research director at the Francis Crick Institute, United Kingdom.

February 16

Study finds premature infants benefit from exclusive human milk-based diet

3116NEC300A recent Baylor College of Medicine study led by Texas Children’s neonatologist Dr. Amy Hair, and published in the journal Breastfeeding Medicine, found that premature infants weighing less than 1,250 grams at birth showed improved outcomes after being fed a human milk-based diet.

 

 

 

February 16

Mata twins celebrate one-year anniversary after historic separation 3116MataFamily300

A year after being separated in a marathon surgery at Texas Children’s Hospital, formerly conjoined twins Knatalye and Adeline Mata are healthy, lively toddlers. Several members of our medical staff involved in the girls’ care got to see how much they have grown and how far they have come during a recent visit to Texas Children’s for their follow-up appointments with pediatric subspecialists monitoring their health and development. Hear some of their reactions and see for yourself how much the girls have progressed.

February 16

Heart Center launches series of educational animated videos 3116animation300

Featuring an armadillo, a bison and robot-like caregivers called Blings, a series of animated videos created by Texas Children’s Heart Center aims to help educate patients and their families about various heart conditions and treatment options. Six of the videos were unveiled at a February 15 red carpet premier and can be accessed on the Texas Children’s website at http://www.texaschildrens.org/hearteducation.

February 23

CVICU physician performs CPR, saves man’s life during spin class

When Dr. Natasha Afonso clipped in to a bike for a spin class on a recent Thursday evening, she didn’t know the skills she uses each day to treat patients in the CVICU would mean the difference between life and death for a fellow rider. Toward the end of the 45-minute, high-intensity class, Afonso heard 50-year-old Scott Corron collapse and fall off his bicycle. Because he wasn’t breathing and had no pulse, Afonso immediately started CPR, an action that ultimately saved Corron’s life.

February 23

New in situ simulation program enhances role clarity in high-risk emergencies 3116sitasim300

Texas Children’s Simulation Center recently launched the first-ever Neonatal Comprehensive In Situ Simulation Program for NICU providers at the Pavilion for Women. The program focuses on improving crisis resource management skills, one of which is role clarity, to ensure all code team members know each other’s specific roles when delivering care to patients during high-risk medical emergencies.

February 23

Texas Children’s helps develop nation’s first hospital-based rapid test for the Zika virus

3116zikalab300Pathologists and clinical laboratory scientists at Texas Children’s Hospital and Houston Methodist Hospital developed the nation’s first hospital-based rapid test for the Zika virus in a matter of weeks as part of the L.E. and Virginia Simmons Collaborative in Virus Detection and Surveillance. Pathologist-in-Chief Dr. James Versalovic and Dr. James Dunn, director of medical microbiology and virology, led Texas Children’s Zika test development team. The new diagnostic test identifies virus-specific RNA sequences to detect the virus and can distinguish Zika virus from other virus infections like Dengue, West Nile or Chikunguny.

February 23

Blaney receives Pioneer Award for contributions in pediatric neuro-oncology The Children’s Brain Tumor Foundation honored Dr. Susan Blaney with the Pioneer Award for Pediatric Neuro-Oncology, celebrating her 25 years of dedication to the search for new and better treatments for children with brain and spinal cord tumors. Blaney’s extensive experience in clinical translational research focuses on developing new treatment strategies for children with brain tumors and other refractory cancers. Blaney has been instrumental in developing more new agent clinical trials than anyone in the field of pediatric oncology.

February 23

Dietrich voted president-elect of North American Society for Pediatric and Adolescent Gynecology

Chief of Pediatric and Adolescent Gynecology Dr. Jennifer Dietrich has been voted president-elect of the North American Society for Pediatric and Adolescent Gynecology. Her tenure as president-elect begins in April. She will be voted in as president in April 2017.

February 23

Texas Children’s Health Plan Center for Children and Women earns accolades for CenteringPregnancy® program Texas Children’s Health Plan’s Center for Children and Women has earned site approval for its CenteringPregnancy® program. The Centering Healthcare Institute (CHI) has awarded both the Southwest and Greenspoint locations the official designation for closely following the CenteringPregnancy® model.

February 23, 2016

22416zikatesting640Pathologists and clinical laboratory scientists at Texas Children’s and Houston Methodist Hospital developed the nation’s first hospital-based rapid test for the Zika virus in a matter of weeks as part of the L.E. and Virginia Simmons Collaborative in Virus Detection and Surveillance.

This collaborative program was established to facilitate rapid development of tests for virus detection in a large metropolitan area. These tests are customized to each hospital’s diagnostic laboratory and designed to provide results within several hours. Before the Zika test was developed, physicians faced the possibility of long delays of testing in local and state public health laboratories and the Centers for Disease Control (CDC).

Texas Children’s Pathologist-in-Chief Dr. James Versalovic and Dr. James Dunn, director of medical microbiology and virology, led Texas Children’s team tasked with developing a rapid test for Zika virus.

Transmitted primarily through mosquito bites, Zika is a flavivirus that contains RNA as its genetic material. This new diagnostic test identifies virus-specific RNA sequences to detect Zika virus and can distinguish Zika virus from other virus infections like Dengue, West Nile or Chikungunya. Every viral particle contains genes in its RNA and these RNA sequences are directly detected on blood, amniotic fluid, urine and spinal fluid.

Currently, only registered patients at Texas Children’s or Houston Methodist hospitals can receive the test but the labs will consider referral testing from other hospitals and clinics in the future.

The test will be initially offered to patients with a positive travel history and symptoms consistent with acute Zika virus infection such as a rash, arthralgias or fever, or asymptomatic pregnant women with a positive travel history to any of the affected countries. The World Health Organization has advised pregnant women to consult their doctors before traveling to places with Zika virus outbreaks and consider delaying travel. The CDC issued similar guidelines to pregnant women last month.

“With travel-related cases of the Zika virus becoming more prevalent in the U.S. coupled with the looming increase in mosquito exposure during spring and summer months, we must be prepared for a surge of Zika testing demand,” Versalovic said. “We must provide answers for anxious mothers-to-be and families who may experience signs and symptoms or may simply have a travel history to these endemic areas.”

Click here for more information about the Zika virus and what Texas Children’s maternal fetal task force is doing to develop strategies based on CDC screening guidelines for pregnant women who may have been exposed to the Zika virus.

22416blaneyaward640The Children’s Brain Tumor Foundation honored Dr. Susan Blaney with the Pioneer Award for Pediatric Neuro-Oncology, celebrating her 25 years of dedication to the search for new and better treatments for children with brain and spinal cord tumors.

Blaney is the deputy director of Texas Children’s Cancer Center, a professor and executive vice chair of the Department of Pediatrics at Texas Children’s and Baylor College of Medicine, and she also serves as vice president of Clinical and Translational Research at Baylor.

Blaney’s extensive experience in clinical translational research focuses on developing new treatment strategies for children with brain tumors and other refractory cancers. Blaney has been instrumental in developing more new agent clinical trials than anyone in the field of pediatric oncology.

Blaney serves as vice chair for the Children’s Oncology Group and was one of the initial members of the Pediatric Brain Tumor Consortium (PBTC). Additionally, she serves as a mentor to numerous pediatric neuro-oncology fellows and faculty who are current or developing leaders in the field. Among other appointments and positions, she is a member of the National Cancer Institute’s (NCI) Clinical Trial Advisory Committee and serves on the Executive Committee for the NCI-funded Pediatric Brain Tumor Consortium. She has served as a member of the Investigational Drug Steering Committee for the National Cancer Institute and as a regular consultant for the Food and Drug Administration’s pediatric Oncology Drug Advisory Committee.

Blaney has published more than 190 articles in peer-reviewed journals and has authored numerous book chapters. She is dedicated to the development of new anti-cancer agents and therapeutic strategies for malignant central nervous system tumors of childhood and to decreasing the morbidity of current therapeutic strategies. In addition, she is passionate about the mentorship of young faculty members in clinical and translational research to ensure that there is sustained leadership in the field.