July 6, 2016

7616drgramatges175On June 23, the Children’s Cause for Cancer Advocacy held a congressional briefing in Washington, D.C., to raise awareness of childhood cancer survivorship.

The purpose of the briefing was to promote the STAR Act (Cancer Survivorship Treatment Access and Research Act), a bipartisan bill with goals of maximizing childhood cancer survivors’ quality of life, moving childhood cancer research forward, and helping kids get access to life-saving treatments.

Dr. Monica Gramatges, a pediatric oncologist and researcher at Texas Children’s Cancer Center, was one of four physicians who spoke to congressional staffers on behalf of the STAR Act. She explained the benefits of the Passport for Care, a web-based clinical decision making tool for survivors and their caregivers, and how the use of this application can overcome many of the geographic, educational, and access barriers faced by survivors.

June 28, 2016

62916usnews640It’s one of parents’ worst fears – their child has a complex or life-threatening illness. How do they decide where to go for the comprehensive care their child needs?

Over the years, the U.S. News & World Report Best Children’s Hospitals rankings have helped thousands of parents identify top sources of care for children with the most difficult medical problems. And Texas Children’s Hospital has consistently been among them.

On the 2015–16 Best Children’s Hospitals Honor Roll, which recognizes pediatric centers that are highly ranked in multiple specialties, Texas Children’s, working closely with academic partner Baylor College of Medicine, ranked no. 4 in the nation for the fifth consecutive year. It is the only children’s hospital in Texas on the Honor Roll.

“We’re rightfully proud of the great work that Texas Children’s does day in and day out on behalf of sick children and their families, but we know we have room for improvement,” said Texas Children’s Physician-in-Chief Dr. Mark W. Kline. “To the degree that the U.S. News survey can help us develop a blueprint for being the world’s best and highest quality pediatric health care institution, we are pursuing that.”

In a process that has become increasingly rigorous and data driven, the U.S. News rankings enable hospitals to look in the mirror and scrutinize themselves.

“Do we like the reflection? Are we as good as we think we are?” asked Dr. Angelo P. Giardino, senior vice president and chief quality officer at Texas Children’s. “In many cases, we are, and we’re thrilled because we are a really great children’s hospital. But there are opportunities where we look in the mirror and we say, ‘We could really do that better.’”

Rankings evolve

Beginning in 1990, as part of the Best Hospitals list, the pediatric rankings were 100 percent reputational for more than 15 years, based entirely on a survey of pediatricians and pediatric specialists across the country, asking them to identify the best children’s hospitals.

When U.S. News decided to rank pediatric hospitals separately from adult hospitals, the publication faced a challenging absence of data. While adult hospital rankings were drawn from Medicare data, no comparable source of information about children’s hospitals was available. As a result, U.S. News enlisted RTI International, a nonprofit research and consulting firm that was already the contractor for the Best Hospitals rankings, to develop a methodology for obtaining data directly from the hospitals and to analyze the results.

The first rankings incorporating such data were published in 2007 as General Pediatrics. Texas Children’s Hospital was listed among the top 30 children’s centers.

In 2008, rankings in six specialties, including cancer and neonatal care, were added to the children’s hospital rankings. In 2009, a newly created Honor Roll listed the 10 children’s hospitals out of 160 surveyed that were ranked in all the specialties, which had been increased from six to 10.

The 2015-16 Honor Roll required a hospital to rank in the top 10 percent in three or more specialties. Only 12 pediatric hospitals qualified among 184 surveyed nationwide. Texas Children’s has appeared on every Honor Roll.

In 2015, Texas Children’s ranked no. 2 in three specialties: cardiology/heart surgery, neurology/neurosurgery and pulmonology. Texas Children’s ranked among the top five hospitals in six specialties and in the top 30 hospitals in all 10 specialties.

“The original purpose of the Best Hospitals rankings was to inform patients and families and help them make decisions,” said Health Rankings Editor Avery Comarow, who has directed the Best Hospitals projects since their beginnings. “I now recognize that we don’t necessarily have to just reflect performance. We can also drive it by incorporating metrics that reflect that goal. Every year, our contractor, RTI International, meets with medical experts to evolve the methodology in ways that not only reflect what children’s hospitals are doing, but ways in which they could and should be doing better.”

Quality framework

Today, the U.S. News Best Children’s Hospitals rankings use a well-accepted framework for evaluating the quality of health care:

Structure: hospital resources related to patient care, such as the ratio of nurses to patients, specialized clinics and programs, and certification by external organizations.

Process: compliance with best practices in diagnosis, treatment, prevention and patient education. As a part of the process, reputation now counts as 16.7 percent of the overall score, down from the original 100 percent.

Outcomes: factors such as rates of survival, infection, mobility and cure.

The increasing emphasis on quality measures had strong support from the late Dr. Bernadine Healy, a former director of the National Institutes of Health, who was health editor of U.S. News before her death in 2011.

“Her expertise and perspective were invaluable,” Comarow said. “She had such a strong sense of the things that were important to patients and families. She brought that same perspective to some of the choices that we made in trying to decide which measures to highlight, what sort of weight to give them, how many hospitals we should assign rankings to, and where we would run out of meaningful data as opposed to numbers that looked OK but were not terribly reliable statistically.”

As U.S. News shifted the emphasis toward quality measures, Texas Children’s shifted coordination of the survey response from its Marketing/PR Department to its Quality and Safety Department.

Team effort

The evolution into quality led us to bring all the chiefs of medical and surgical services to the table,” said Mary Jo Andre, senior vice president and chief nursing officer and former senior vice president of Quality and Safety. “The more that quality and best practices were built into the survey, the more accountability of the survey shifted from an administrative standpoint to the medical staff.”

To help build physician engagement, Giardino and Thomas Luerssen, chief quality officer – surgery, were appointed quality officers for Pediatrics and Surgery, respectively, in 2013. The next year, Giardino was named to his present position as chief quality officer of Texas Children’s, and Eric Williams, succeeded him as quality officer for Pediatrics. They work closely with teams of physician section chiefs, practice administrators and data specialists.

Although only 10 clinical areas are ranked, a total of about 20 different services contribute to the survey, such as Radiology, Emergency Services, Intensive Care, Social Work and Nutrition. For example, nursing certification, attention to safe practices and increasing specialty roles of nurses appear in each section of the survey. Texas Children’s receives points for safety because of the hospital’s Magnet certification by the American Nurses Credentialing Center.

“Any outcome is a partnership of nursing and physicians,” Andre said. “The question directly related to nursing is about staffing. Seeing how we compared to the rest of the country has been a good thing for nursing, because it’s driven us to have higher standards as well.”

More than 100 people at Texas Children’s contribute to the survey each year, submitting more than 1,500 survey elements in all. Texas Children’s also is represented in four of the working groups that RTI consults each year in continuing to refine the methodology. Involvement in quality improvement at Texas Children’s is even more far-reaching. More than 400 staff members have been trained in Advanced Quality Improvement.

“Quality improvement, which Texas Children’s is passionate about, extends everywhere,” said Dr. Charles D. Fraser, Jr., chief of Congenital Heart Surgery and surgeon-in-chief at Texas Children’s. “Quality starts immediately when the patient or family arrives here. Everyone is important, whether you’re in housekeeping or food services, the cardiac intensive care unit or are an administrative executive. Everyone is responsible for quality.”

Gap analysis

Texas Children’s analytics team provides data to each section chief with a detailed analysis of the gaps between the section and comparable data from top-ranked peer institutions in the Best Children’s Hospitals rankings. The service chiefs and their clinical and administrative teams review the data closely and objectively, identifying gaps and opportunities to improve quality, access or outcomes.

For example, in Texas Children’s Diabetes and Endocrinology section, gap analysis revealed several opportunities for improvement that are being addressed. To help deal with limited patient access, four new pediatric endocrinologists have been hired. To reduce disease complications, timely alerts now appear on physicians’ computers, reminding them to schedule their patients for tests for thyroid problems, kidney complications and early signs of diabetic retinopathy, which is associated with blindness.

“The U.S. News rankings are a wonderful opportunity to shine a light on potential problem areas and to allow us to make the care that we deliver better, more effective and more patient centered,” said Dr. Jake Kushner, chief of Diabetes and Endocrinology at Texas Children’s.

The rankings not only help identify gaps where improvements are needed, but also provide data to build the case for needed changes.

“Many of the service chiefs and practitioners have said, ‘We’ve been wanting this – this process, this equipment, this type of clinic – for years, and here it is in the survey,’” said Terri Brown, assistant director of Clinical Outcomes and Data. “So they are able to leverage the survey to help achieve what they already know to be good ideas.”

As the Best Children’s Hospitals survey focuses more and more on ways to improve outcomes, the transparency and accountability of the published rankings are helping to improve children’s health care nationally.

“If you look at the hospitals on the Honor Roll, we’re all delivering great care to children and families,” Giardino said. “Everybody’s working hard to get better. So the bar keeps moving higher. And that’s the whole point.”

62916NolanDayRings640Watch ABC-13’s story about 4-year-old Nolan celebrating the end of his long journey with cancer by ringing the end-of-treatment bell.

June 21, 2016

62216globalhealth640Texas Children’s global health initiative recently expanded its services in Europe and Africa, enabling more children and adults across the globe to receive quality medical care. Two of the initiatives will help children in Africa who are suffering from cancer. The third effort will aid both adults and children living in Romania with HIV, hepatitis and tuberculosis.

Romania

The Romania initiative occurred June 6 when Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital (BIPAI) formally opened the expansion of its center of excellence in Constanta, Romania, a port city hit hard by the AIDS epidemic.

“The addition of a third floor to our center of excellence marks an important milestone in our life-saving work here in Romania,” said Dr. Mark W. Kline, Texas Children’s Hospital physician-in-chief and BIPAI president. “What began as a center for children with HIV now has transitioned to a center for the long-term care of adults with HIV, along with the identification and care of patients with hepatitis and tuberculosis.”

AbbVie and the AbbVie Foundation (formerly Abbott and Abbott Fund) have been the lead sponsor of the BIPAI Romania program since its launch 15 years ago in 2001, investing $7.7 million in its HIV/AIDS and hepatitis programs, and providing $35.9 million in medications in partnership with AmeriCares.

“We are grateful for the opportunity to partner with BIPAI in Constanta for the past 15 years,” said Melissa Walsh, vice president of the AbbVie Foundation. “The program has become the model for many pediatric HIV/AIDS centers of excellence around the world, and we are proud to support the broadening of its life-saving work for patients, including liver disease.”

Malawi

The AbbVie Foundation, along with the Abbott Fund, also helped fund the recent cancer initiative in Malawi. On June 9, BIPAI, the AbbVie Foundation and the Malawi Ministry of Health reopened two renovated pediatric wards and dedicated a new pediatric hematology/oncology unit at Kamuzu Central Hospital.

“We are honored to celebrate this milestone for the Baylor College of Medicine and Texas Children’s Hospital,” Walsh said. “The Malawi program has transformed the lives of thousands of children and their families living with HIV/AIDS and we are so proud to support the expansion of that work into the pediatric cancer space.”

In addition to AbbVie, the Chevron Corporation also supports the Malawi program, funding its only pediatric oncologist, Dr. Peter Wasswa of Baylor College of Medicine and Texas Children’s Cancer Center.

“Today’s ceremony provides further evidence of our continued commitment to the children of Malawi,” said Michael Mizwa, chief operating officer, BIPAI, and director, Texas Children’s Global Health. “We look forward to another decade of expanding our programs to meet the needs of sick children, including care and treatment, professional education for physicians and other healthcare professionals, and ground-breaking research.”

Botswana

The second effort dedicated to helping children in Africa with cancer occurred on June 13 in Botswana when the Botswana-Baylor Children’s Center of Excellence and the government of Botswana signed a memorandum of agreement to build the first children’s hematology and cancer center of excellence in Gaborone.

“Approximately 40,000 children a year are diagnosed with cancer in sub-Saharan Africa and 20 percent of those children survive, compared with 80 percent in the U.S.,” said Dr. David Poplack, director of Texas Children’s Cancer and Hematology Centers. “This COE (Center of Excellence), in partnership with the Botswana Ministry of Health, will change those numbers in favor of the children of Botswana.”

When pediatric oncologists from Texas Children’s Hospital began working at Princess Marina Hospital in Gaborone, it was the first pediatric oncology program on the continent. The recent agreement between the Botswana-Baylor Children’s Center of Excellence and the government of Botswana expands that commitment to include the first stand-alone cancer center of excellence devoted exclusively to the treatment of children with cancer and blood diseases.

“The purpose of this agreement is to provide finance, design, construction, operation and maintenance of the state-of-the-art Botswana Children’s Hematology and Cancer Center which will be built next to the teaching hospital at the University of Botswana,” said Shenaaz el Halabi, permanent secretary at the Ministry of Health. “The Ministry of Health has had good relations with BIPAI dating as far back as 1999, which gave birth to the Baylor Children’s Center of Excellence in 2003. Since 2006, pediatric oncologists from Texas Children’s have been working at Princess Marina Hospital.”

The partnership responsible for the development and management of the Children’s Cancer Center includes: the Botswana Ministry of Health, Baylor College of Medicine Pediatric AIDS Initiative (BIPAI) and Texas Children’s.

62116USNEWS640The 2016-17 edition of Best Children’s Hospitals by U.S. News & World Report ranked Texas Children’s Hospital fourth in the country out of nearly 200 pediatric institutions. For the eighth straight year, Texas Children’s Hospital was placed on the Best Children’s Hospital Honor Roll, and for the first time Texas Children’s has a no. 1 ranked service – Pulmonology.

Texas Children’s national rankings for each subspecialty area are:

#1     Pulmonology
#2     Cancer

#2     Cardiology and Heart Surgery
#2     Neurology and Neurosurgery
#3     Nephrology (kidney disorders)
#5     Urology
#6     Gastroenterology & GI Surgery
#11   Diabetes and Endocrinology
#14   Neonatology
#21   Orthopedics

Five services are ranked in the top 5 percent, and two services are in the top 10 percent. Also, based on last year’s rankings, eight services made gains or maintained their current top rankings.

“These rankings continue to reflect the steadfast commitment Texas Children’s has to providing the highest-quality patient care and outcomes possible for the families we serve,” said President and CEO Mark A. Wallace. “The diligent efforts and enthusiasm our staff and employees display every day for Texas Children’s mission, along with our outstanding results in this survey, proves we are unquestionably the best in Texas.”

To be considered for the honor roll distinction, a hospital must have high rankings in at least three specialties. Texas Children’s Hospital is 1 of only 11 hospitals on the Honor Roll this year. We are also the only pediatric hospital in Texas – and the Southwest region – to make the Honor Roll all eight times since the specialty-specific rankings began in the 2009 – 2010 survey year.

In addition to ranking children’s hospitals overall, U.S. News & World Report also ranks the top 50 pediatric hospitals in 10 major subspecialty areas.

“From a measurement perspective, our survey results demonstrate how hard we’re working as an organization to deliver high quality care to our patients,” Wallace said. “The more consistently we deliver high quality care and the safer we deliver that care to our patients, the better their outcomes are, and the better our overall numbers are.”

The results also reflect the diligent efforts of a solid structure focused on the U.S. News survey. The process of compiling and refining our data is an ongoing challenge, which will continue to improve under the leadership of Texas Children’s USNWR Operations team, including Dr. Angelo Giardino, Trudy Leidich, Paola Alvarez-Malo, Elizabeth Pham, Roula Smith.

“These rankings continue to reflect what we all already know, that the trajectory of Texas Children’s is absolutely incredible,” Wallace said.

For more information about the U.S. News rankings, visit:

U.S. News & World Report Best Children’s Hospitals Honor Roll 2016-2017
Rank Hospital
1 Boston Children’s Hospital
2 Children’s Hospital of Philadelphia
3 Cincinnati Children’s Hospital Medical Center
4 Texas Children’s Hospital, Houston
5 Seattle Children’s Hospital
6 Ann and Robert H. Lurie Children’s Hospital of Chicago
7** Children’s Hospital Los Angeles
7** Children’s Hospital of Pittsburgh of UPMC
9 Children’s Hospital Colorado, Aurora
10** Lucile Packard Children’s Hospital at Stanford, Palo Alto, Calif.
10** Nationwide Children’s Hospital, Columbus, Ohio

*2 points per specialty for ranking in highest 5 percent of hospitals; 1 point if in next 5 percent.

**Tie.

June 1, 2016

6116poplackaward640Dr. David Poplack, director of Texas Children’s Cancer and Hematology Centers, was recently honored with the American Society of Pediatric Hematology/Oncology (ASPHO) Distinguished Career Award.

ASPHO is the major professional society for physicians specializing in the field of childhood cancer and blood diseases. This award is given each year to a renowned individual who has made a significant impact on their subspecialty through research, education, patient care and advocacy.

Throughout his remarkable career, Poplack has made numerous contributions to the advancement of patient care, pediatric cancer research and the education of trainees all over the world. During his time as the head of the Clinical Pharmacology and Experimental Therapeutics program at the National Cancer Institute (NCI), he helped develop new treatment approaches for patients with leukemia and other pediatric cancers and pioneered the development of a model extensively used for more than 20 years in the development of anti-cancer drugs. He led the advancement of new pediatric leukemia treatments to help minimize effects on long-term survivors, which included the establishment of the Childhood Cancer Survivor Clinic at the NCI. His revolutionary work has expanded through his service on committees for the Food and Drug Administration, the Institute of Medicine and NCI. He has also served, and currently serves, on multiple national medical advisory boards including Alex’s Lemonade Stand, Curing Kids Cancer, Hyundai Hope on Wheels Program and St. Baldrick’s Foundation.

Since joining Texas Children’s Hospital in 1993, Poplack has continued to strive for the best and most advanced care of children with cancer, including those in underserved populations. In 2001, Poplack developed the Vannie Cook Clinic, a hematology/oncology clinic in McAllen, Texas. He also established Texas Children’s Cancer and Hematology Center’s International Program, which provides care in four sub-Saharan African countries. Most recently, Poplack has headed the development and implementation of the Passport for Care program, a web-based decision support service that provides long-term childhood cancer survivors with individualized follow-up recommendations. This resource is implemented and used by more than 125 children’s cancer centers.

Under his guidance, the Texas Children’s Cancer and Hematology Program has grown to become the largest pediatric cancer and hematology center in the United States. When Poplack took the helm 23 years ago, the Cancer Center had only six faculty, 42 employees and one research lab in 1993. Today, the Cancer Center boasts 165 faculty, 800 employees and 42 different labs dedicated to pediatric cancer research.

Poplack has also made an immense impact on education. He is co-editor of “Principles and Practice of Pediatric Oncology,” the leading textbook in the field, currently in its seventh edition. He has also authored more than 360 original scientific articles, book chapters and reviews, and, as the director of the largest pediatric hematology/oncology fellowship training program in the United States, Poplack has trained more than 120 pediatricians to become pediatric cancer and blood disease sub-specialists. He also serves as the principal investigator of a prestigious NCI-funded pediatric oncology training grant that has trained 27 junior faculty scholars in clinical research. He also has trained a large number of pediatric oncologists in cancer pharmacology and new drug development.

Poplack is a world recognized leader in the field of pediatric hematology/oncology, an extraordinary mentor and continues to have a major and widespread impact on improving the care of children with cancer and blood disorders.

“Dr. Poplack is an outstanding mentor and one of the most visionary leaders in our field,” said Dr. Susan Blaney, deputy director of the Cancer Center and executive vice chair of Research at Baylor. “His influence has been felt worldwide in all areas of pediatric oncology, and I don’t know anyone more deserving of this award than Dr. Poplack.”

Click here for more information about Texas Children’s Cancer Center.

May 18, 2016

51816drparsons175

Dr. Will Parsons, a pediatric oncologist at Texas Children’s Cancer Center and associate professor of pediatrics at Baylor College of Medicine, will participate in the efforts to accelerate cancer research through the National Cancer Moonshot Initiative. Parsons will join the National Cancer Institute’s Blue Ribbon Panel Working Group on Pediatric Cancer, which is providing insight and direction to the Moonshot initiative.

The Moonshot initiative was announced in January by President Barack Obama and is being led by Vice President Joe Biden. The initiative aims to accelerate current cancer research efforts and break down barriers to progress, making more therapies available to more patients, while also improving the ability to prevent cancer and detect it at an early stage.

The NCI, in consultation with the National Institutes of Health and the White House, assembled the Blue Ribbon Panel, a working group of the National Cancer Advisory Board, to provide expert advice on the vision, proposed scientific goals and implementation of the National Cancer Moonshot. The panel will consider how to best advance the themes proposed for the Moonshot, including an intensive examination of the opportunities and impediments in cancer research.

The Blue Ribbon Panel’s working groups, including the pediatric cancer group, will gather input from the cancer research community and industry across specific disciplines and sectors. The findings and recommendations of the panel and its working groups will be reported to the National Cancer Advisory Board (NCAB) later this summer. The NCAB will use the panel’s findings to provide final recommendations to the NCI director, who will in turn deliver a report to the White House Moonshot Task Force and ultimately to the President.

“I’m excited about the potential of the Moonshot initiative to improve care for children with cancer through collaborative research,” Parsons said. “We look forward to contributing to these discussions based on our experience at Texas Children’s Cancer Center.”

In addition to coordinating the Working Groups, the Blue Ribbon Panel is accepting cancer research ideas to be considered under the Moonshot from the scientific community and general public. Individuals and groups are encouraged to submit their ideas through July 1 to CancerResearchIdeas.cancer.gov.

Parsons is director of the Pediatric Center for Precision Oncology at Texas Children’s Cancer Center, as well as the co-director of the Brain Tumor Program and the Cancer Genetics and Genomics Program. He specializes in the treatment of children with brain and spinal cord tumors, and his team’s research has been critical to the understanding of genes involved in pediatric solid tumors, leukemias, and histiocytic disorders.

In addition, Parsons’ research program focuses on the clinical application of genomic technologies in pediatric cancer care. He is the co-principal investigator with Dr. Sharon Plon, professor of pediatrics – oncology at Baylor, on the Baylor Advancing Sequencing in Childhood Cancer Care, or BASIC3, study, a National Human Genome Research Institute and National Cancer Institute-funded Clinical Sequencing Exploratory Research project to examine the usefulness of tumor and germline whole exome sequencing in children newly diagnosed with certain cancers. He also serves as the Children’s Oncology Group study chair for the NCI Pediatric MATCH study, a precision oncology clinical trial for children with relapsed and refractory cancers that is planned to open in late 2016.