February 2, 2016

8515Drzoghbi175Dr. Huda Zoghbi, director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s, will receive this year’s prestigious Jessie Stevenson Kovalenko Medal for her pioneering advancements in neuroscience research.

The National Academy of Science (NAS) presents this award every two years for outstanding research in the medical sciences. The Kovalenko Fund was gifted by Michael S. Kovalenko in 1949 in memory of his wife, Jessie Stevenson Kovalenko. For the last 63 years, the NAS has chosen distinguished scientists who have made landmark discoveries in medical research to receive this medal.

“Zoghbi unraveled the molecular basis of Spinocerebellar ataxia and Rett syndrome, providing novel insight into the pathogenesis of a broad range of neurologic disorders,” NAS Home Secretary Susan R. Wessler said. “Over the years, she has received numerous awards and prizes that honor her leadership in neuroscience research and exemplary mentorship to young neuroscientists. We couldn’t be more excited about this latest award. Her research initiatives have provided much needed rays of hope for many patients and their families.”

Zoghbi, who is a professor of molecular and human genetics, pediatrics, neurology and neuroscience at Baylor College of Medicine, has made several seminal discoveries in diverse areas of neuroscience. Her work has significantly furthered our understanding of neurodevelopmental and neurodegenerative disorders and revealed novel strategies to reverse these conditions. In addition, her forays in basic developmental neurobiology have led to important insights in a broad range of conditions from hearing loss to colon cancer.

Among her many scientific accomplishments, Zoghbi is widely recognized for her pioneering work on Rett syndrome, a form of autism common among girls. In 1999, she and her colleagues discovered that Rett syndrome is caused by loss-of-function mutations in the X-linked gene MeCP2 (methyl-CpG-binding protein 2) which established it as the first autism spectrum disorder that is largely caused by sporadic gene mutations. She would go on to demonstrate that the brain is exquisitely sensitive to levels of what she terms the “goldilocks” protein, MeCP2, and that doubling MeCP2 levels causes another devastating neurological syndrome among boys.

Recently, her lab showed that using small antisense oligonucleotides to normalize MeCP2 levels in the brain reversed the debilitating symptoms of MeCP2 duplication syndrome in a mouse models of that disease.

Zoghbi will receive the Jessie Stevenson Kovalenko Medal on Sunday, May 1, at the National Academy of Science’s 153rd Annual Meeting.

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Texas Children’s is set to receive a $1 million grant from the Texas Department of State Health Services (DSHS) to put toward its newly constructed Special Isolation Unit at Texas Children’s Hospital West Campus. The funds, to be delivered during the next five years, will specifically go toward Ebola preparedness activities that bolster employee safety and quality of care.

Texas Children’s began ramping up its Ebola preparedness and decided to build a special isolation unit almost a year ago, shortly after an unprecedented outbreak of the disease resulted in the realization that we must be prepared to handle emerging infections as an institution. As a result, the state and the Centers for Disease Control and Prevention designated Texas Children’s Hospital as one of several pediatric Ebola treatment centers countrywide.

Texas Children’s Special Isolation Unit is the only one of its kind in Texas and the southwest region, and is among the few in the United States designated just for children. Located on the fifth floor of West Campus, the eight-bed unit is fully equipped to care for any infant or child with a serious communicable disease and has all of the measures available to assure safety of the health care team, other patients and their families.

As a condition of the DSHS grant, members of the National Ebola Training and Education Center (NETEC) – created to ensure health care providers and facilities are prepared to safely identify, isolate, transport and treat patients with Ebola and other emerging threats. – recently visited the Special Isolation Unit. During NETEC’s two-day trip, members of the newly formed federal entity toured the Special Isolation Unit and spoke with leaders in detail about the formation of the unit, its capabilities and its potential usages.

“We were glad to have subject matter expertise tour our facility and provide knowledge and insight that will help us improve patient and staff satisfaction,” said Special Isolation Unit Medical Director Dr. Gordon Schutze. “They were very complimentary of the unit and told us we were fortunate to have leadership that is very supportive of doing what is best for their employees and patients.”

Once received, a portion of the DSHS grant will be used to compensate Texas Children’s for the Ebola preparedness activities undertaken since July 2014. Unit and West Campus leaders are working together to identify the best use of the remaining funds and how they can be invested to better health care professional safety and quality of care.

January 19, 2016

12016CancerCenterresearchersinside640The American Society of Hematology (ASH) recognized three researchers from Texas Children’s Cancer Center and Baylor College of Medicine for their work in advancing our understanding of disease pathogenesis and exploring novel innovative approaches for the treatment of pediatric cancers.

Dr. Rikhia Chakraborty, instructor of pediatrics and part of the Histiocytosis Research Lab at the Cancer Center, received a 2016 Basic Junior Faculty Scholar Award for her study investigating disease pathogenesis of Langerhans Cell Histiocytosis, a disease that occurs when the body accumulates too many immature Langerhans cells, a type of white blood cell that normally helps the body fight infection. Scholar awards support fellow and junior faculty dedicated to careers in hematology research as they transition from training programs to careers as independent investigators. The award is for $150,000 over two to three years.

Dr. Maksim Mamonkin, a postdoctoral associate in the Center for Cell and Gene Therapy, received a 2016 Basic Research Fellow Scholar Award for his study on developing targeted therapy to treat T cell malignancies. This research award will provide $100,000 over two to three years and will support transition from training programs to an independent investigator career.

Dr. Rayne Rouce, instructor in the Center for Cell and Gene Therapy, has been named a 2016 award winner of the ASH and the Harold Amos Medical Faculty Development Program of the Robert Wood Johnson Foundation. She delivered a presentation on her work, which focuses on immunotherapy for the treatment of pediatric cancer. She will also receive a $400,000, four-year grant to further her work.

January 12, 2016

11316perioperativeinside640If you ask Nakeisha Archer, president-elect of the Greater Houston Chapter of the Association of periOperative Registered Nurses (AORN), who inspired her to pursue nursing, there’s one person who comes to mind – her grandmother.

“When I was a little girl, my grandmother shared stories about how she loved taking care of patients in their homes,” Archer said. “She was a private duty nurse and the joy she derived from helping others motivated me to become a nurse.”

After graduating from nursing school with several clinical rotations under her belt, Archer spent six years as a labor and delivery nurse, which included a few years as a travel nurse. Before obtaining her MBA in health care management, she realized her niche was in the operating room (OR).

“I spent a lot of time in the OR as a labor and delivery nurse but I knew there was more to learn,” Archer said. “After completing a perioperative internship program, that’s when my passion for periop began.”

As assistant director of Perioperative Services at Texas Children’s Pavilion for Women, Archer leads a dynamic team of more than 40 nurses who assist with the planning, implementation and evaluation of patient care before, during and after surgery. These activities include patient assessment, creating and maintaining a sterile and safe surgical environment, providing pre- and post-operative patient education, monitoring the patient’s physical and emotional well-being and working closely with the surgical team to provide safe patient care during each phase of the surgical care process. Archer also collaborates with her non-nursing team whose roles are critical to the perioperative process. These include secretaries who schedule new cases, surgical technologists who scrub the cases, and perioperative care technicians and anesthesia technicians who provide specialized team support.

“Perioperative includes the entire surgical experience,” Archer said. “We see between 175 to 210 cases per month which include open, robotic and laparoscopic surgeries to treat a number of gynecological conditions including cancers, urological issues, as well as general surgery, fetal interventions, caesarean deliveries and in vitro fertilization procedures.”

The Pavilion for Women has four Main OR’s, two OR’s in labor and delivery, one procedure suite in the Main OR, and two procedure rooms in the Reproductive Endocrinology and Infertility Clinic. Two more Pavilion for Women Main OR surgical suites will open in May 2016 bringing the total to six OR’s to meet the increasing demand for perioperative services.

Archer says the need to hire and retain experienced perioperative nurses to fill these new positions is one of her top priorities. She says the best way to home “grow” our nursing staff is by providing consistent educational tools and internship programs to cultivate their skills so they can easily adapt to this fast-growing nursing specialty.

“We have a lot of openings right now in periop on the Pavilion side because we’re growing,” Archer said. “Most hospitals that do not have a shortage of experienced OR nurses offer a consistent internship and residency program every six months. When you keep that pipeline going and keep those nurses coming in and consistently train them, they will be ready to be placed in their new roles.”

Since joining the Pavilion for Women two years ago, Archer is thrilled to offer the second perioperative internship program for nurses later this month. This endeavor, which will continue every six months, is part of a joint partnership with Texas Children’s Pediatric Perioperative Services.

When Archer assumes her position as AORN president in May, her passion to advance educational opportunities for nurses will be one of her primary goals.

“One of the things that I think we as leaders don’t always do is have a really good succession plan for our nurse leaders as well as our nurses who are leading at the bedside,” Archer said. “We need to provide them with opportunities to grow and re-energize their periop voices by engaging members around issues that impact them.”

Leading a multi-generational nursing workforce has become a tremendous challenge too. Archer plans to collaborate with nursing leaders to help reframe perceptions about generational differences and to view these attitudinal and behavioral differences as potential strengths.

While much of Archer’s day is spent attending meetings, rounding with nursing and physician staff and staying abreast of all the cases scheduled for each day, she says at the end of the day, her greatest joy is taking care of her patients – just like her grandmother did.

“On a really good day, I can go to our waiting area and have conversations with some of the patients and families, and make sure that things are going well,” Archer said. “That’s really the fun parts of the job. If we could do that all day, it would be really good.”

January 5, 2016

8515Drzoghbi175Dr. Huda Zoghbi, professor of molecular and human genetics at Baylor College of Medicine, and director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s, will be honored with the 2015 Vanderbilt Prize in Biomedical Science.

She is the 10th recipient of the award given by the Vanderbilt University School of Medicine to recognize women scientists with a stellar record of research accomplishment who have also mentored other women in science.

Prize winners receive an honorarium, deliver a Flexner Discovery Lecture, meet with Vanderbilt faculty and mentor Vanderbilt Prize Scholars – women who are pursuing graduate studies in the biomedical sciences at the medical school.

Zoghbi will receive the prize on April 21, 2016, when she is scheduled to give the Flexner Discovery Lecture at Vanderbilt.

“Huda Zoghbi’s progression from a young woman interested in science to one of the world’s foremost physician-scientists working on the genetic bases of neurological diseases is fascinating and inspiring,” said Dr. Lawrence Marnett, associate vice chancellor for research and senior associate dean for biomedical science, at Vanderbilt.

Zoghbi has been instrumental in finding the genes for Rett Syndrome, spinal cerebellar ataxia 1 and IMath1, which is essential for generation of inner ear hair cell.

She is a member of the Institute of Medicine and the National Academy of Sciences and has received numerous awards throughout the years. She is committed to mentoring young scientists, and one-fourth of her former trainees are women.

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Bench and Bedside is a digest of the previous month’s stories about the clinical and academic activities of our physicians and scientists. We welcome your submissions and feedback.

December 1

Texas Children’s Fetal Center celebrates 400 miracles at patient reunion

Hundreds of families from around the country traveled to Houston to attend Texas Children’s Fetal Center family reunion. Since its inaugural event in 2007, the reunion provided an opportunity for physicians and staff to reunite with patient families who received life-saving medical and surgical care at our fetal center.

December 1

Texas Children’s awards pediatric pilot grants to 10 promising researchers

Ten promising researchers received the 2015 Pediatric Pilot Awards Research grants worth up to $50,000. The grants will provide initial start-up funding for research projects that have the ultimate goal of enhancing patient outcomes.

December 8

Dr. Mary Brandt elected to ACS Medical Student Education Committee

Dr. Mary Brandt, pediatric surgeon and director of the Adolescent Bariatric Surgery Program and the Anorectal Malformation Clinic at Texas Children’s, has been elected to the Medical Student Education Committee of the American College of Surgeons, which addresses the educational needs in surgery for medical students during all four years of medical school.

December 15

Texas Children’s Special Isolation Unit earns award from Texas Department of Health Services

Texas Children’s Special Isolation Unit, the only pediatric-focused unit of its kind in Texas and the Southwest, was recently awarded the Texas Department of Health Services 2015 Texas Preparedness Leadership Award. The annual award recognizes exceptionally meritorious achievements in local, regional or state Public Health Emergency Preparedness and Healthcare Systems Preparedness Programs.

December 15

Texas Children’s Main Campus Urgent Care opens

1516MCUrgentCare300Texas Children’s recently opened a 4,100-square-foot urgent care clinic on the second floor of the Abercrombie Building, creating a system-wide solution to effectively manage the Emergency Center’s (EC) low acuity patient population. The clinic has a dedicated staff of physicians, advanced practice providers, nurses and clinical support staff. The new urgent care has already helped lighten the load of the EC, seeing about 30 patients a day, or 25 percent of the EC’s daily patient volume. Wait times for patients with low-acuity illnesses also have decreased significantly.

December 15

Texas Children’s oncologists contribute to leading textbook in field

1516PoplackBook300Dr. David Poplack, director of Texas Children’s Cancer and Hematology Centers, and numerous members of his medical staff helped write the recently published, 7th edition of Principles and Practice in Pediatric Oncology. This leading textbook provides the most comprehensive resource on the biology and genetics of childhood cancers.

 

December 15

Spotlight on Adult Congenital Heart Disease Program

1516achd300About 40,000 babies are born each year with a congenital heart disease, the most common birth defect. These children grow up with their conditions and are part of a growing population of adults with congenital heart disease. Texas Children’s Adult Congenital Heart Disease Program allows patients to continue their care at their childhood medical home as adults.

 

December 22

Heart Center experts present at Pediatric Cardiac Intensive Care Society 11th International Meeting

1516PCICS300Intensivists, cardiologists, cardiovascular surgeons, nurses, and outcomes and quality experts from Texas Children’s Heart Center and Baylor College of Medicine served as presenters and moderators during the Pediatric Cardiac Intensive Care Society (PCICS) 11th International Meeting held December 9 through 11 in Houston.

 

December 22

Surgical Research Day 2016 to feature new poster session

Plans are underway for the sixth annual Edmond T. Gonzales, Jr., Surgical Research Day which will be held on May 6, 2016. At this session, poster authors will have an opportunity to present their research to reviewers as scoring takes place.

December 22

L. E. Simmons Chair in Orthopedics awarded to Dr. John Dormans

Chief of Orthopedics Dr. John Dormans was recently awarded the L.E. Simmons Chair in Orthopedics. Provided by the Houston Endowment in recognition of Simmons, who served as chairman of Texas Children’s Board of Trustees from 2003-2004, the purpose of this chair is to support orthopedic research, education, clinic program development and advocacy at Texas Children’s.

December 22, 2015

93015JohnDormans175Chief of Orthopedics Dr. John Dormans was recently awarded the L.E. Simmons Chair in Orthopedics. Provided by the Houston Endowment in recognition of Simmons, who served as chairman of Texas Children’s Board of Trustees from 2003-2004, the purpose of this chair is to support orthopedic research, education, clinic program development and advocacy at Texas Children’s.

“I’m extremely honored to be awarded this distinction,” Dormans said. “My vision is for Texas Children’s to be the best place in the world for families to receive pediatric orthopedic care.”

Dormans has distinguished himself nationally and internationally as a leader in the field and is a highly regarded clinician and surgeon with accomplishments in research and teaching. His primary clinical focus is on the treatment of complex spinal disorders and orthopedic oncology care. He previously served as president of the following organizations: Pediatric Orthopaedic Society of North America; International Society of Orthopaedic Surgery and Traumatology (SICOT-USA); the Board of Directors of Orthopaedics Overseas; and the Scoliosis Research Society’s 50th anniversary meeting. He is current president of World Orthopedic Concern. In addition, he served as president of the Children’s Hospital of Philadelphia (CHOP) Medical Staff (1999-2001).

Dormans obtained his undergraduate degree at Indiana University in Bloomington, Indiana and went on to earn his medical degree at the university’s school of medicine in Indianapolis. He then completed his residency in orthopedic surgery at Michigan State University, followed by a clinical pediatric orthopedic fellowship at The Hospital for Sick Children in Toronto, Ontario. He rounded out his post-graduate training with programs at Harvard’s School of Public Health, CHOP and The Wharton School of the University of Pennsylvania.

Dormans has been an invited lecturer in more than 50 countries, published more than 340 articles, authored more than 140 chapters and wrote five books. He has received numerous awards including the Jesse T. Nicholson Award for Excellence in Clinical Teaching from CHOP, where he served as chief of orthopedic surgery prior to joining Texas Children’s and Baylor, and the Dean’s Award for Excellence in Clinical Teaching from Penn.

With seven specialty clinics and more than 20 physicians and physician assistants, the Texas Children’s pediatric orthopedics program cares for children in Houston, across the nation and internationally, treating everything from minor fractures to complex disorders, ensuring the highest level of individualized care for pediatric patients from newborns to young adults.