Infectious Diseases – Page 3 – Texas Children's News

May 3, 2016

On April 22, Sen. John Cornyn of Texas listened to Texas Medical Center doctors and Houston city officials break down research efforts on the Zika virus as mosquito season gets underway. The roundtable discussion was held at Texas Children’s Hospital and included a tour of the lab where research is being done and where Texas Children’s and Houston Methodist Hospital developed the nation’s first hospital-based rapid test for the Zika virus.

The virus, which has spread rapidly through Central and South America in the last year, is transmitted between humans primarily through mosquito bites. People may not realize they’ve been infected with Zika virus because the majority of people will develop an asymptomatic or mild flu-like infection. However, the virus has heightened concern among pregnant women since it may increase the risk of microcephaly, a rare neurological birth defect in which babies are born with abnormally small heads.

While there is no vaccine to protect against Zika infection, doctors are encouraging people, particularly pregnant women, to refrain from traveling to areas where the outbreak is growing. The only way to prevent infection is to avoid getting mosquito bites.

Cornyn said what he learned from the roundtable discussion was that the risk of under reacting to the Zika virus is too high and that the virus will be a problem in the United States if it is not stopped in Central and South America. As a result, he said he will recommend to Congress that action continue to be taken and that dollars continue to be allocated to taking a look at what needs to be done to stop what he called a devastating virus.

“We need to make sure we remain vigilant,” Cornyn said. “And, thanks to the great scientists and medical professionals we have here in Houston, Texas and around the country, I’m confident we will be at the cutting edge of new discoveries that will help public health across the globe.”

Click here to read excerpts from the roundtable discussion and here for more information on the Zika virus.

April 19, 2016

Two decades after Texas Children’s Hospital opened its doors in 1954, the hospital’s medical staff was called on to care for one of the most famous patients in the world – David Vetter, better known as “the bubble boy.”

David’s life, Texas Children’s involvement in his care and the advancements that have been made in the field of immunology, allergy and rheumatology were the topic of two recent Forums Luncheons hosted by our Office of Development to help engage current and potential donors in our mission.

At the River Oaks event and the one held in The Woodlands, former members of David’s care team and members of David’s family described the little boy’s historic journey, which began on September 21, 1971, at Texas Children’s Hospital.

“David was born with severe combined immunodeficience or SCID,” said Dr. William Shearer, the former section chief of Allergy and Immunology. “The hereditary disease, which dramatically weakens the immune system, forced David to live in a clear sterile chamber that resembled a bubble.”

Shearer and other members of Texas Children’s medical staff, including Dr. Imelda Hanson, a physician in Immunology, Allergy and Rheumatology, cared for David until he died of Burkitt’s lymphoma on February 22, 1984, four months after receiving a bone marrow transfusion from his sister. It was later discovered that her marrow contained traces of a dormant virus – Epstein-Barr – which had been undetectable in the pre-transplant screening.

But, as former members of the boy’s medical staff explained, neither David’s life nor his death were in vain.

The dark-haired boy whose face covered magazines across the globe changed the face of immunology here at Texas Children’s and nationally, giving children born today with SCID a good chance at living a normal life. David, who would have been 40 this year, also paved the way for Texas Children’s Hospital to become an international referral center for families worldwide seeking hope and advanced, comprehensive diagnoses, treatment and care, said Physician-in-Chief Dr. Mark W. Kline.

“A few years after David’s passing in 1989, Texas Children’s Hospital was still primarily a regional hospital,” Kline said at the luncheons.” Today, we treat patients from all 50 states and about 60 countries. In fact, we are now an international referral center for some of the world’s most complex cases.”

Many of those cases are children with SCID and almost all benefit from the great strides in SCID research Shearer and Hanson have made after David’s death.

Shearer, for example, helped create the David Center at Texas Children’s Hospital. The center provides state-of-the art care and cutting-edge research for immune system diseases that make children susceptible to auto immunity and infectious diseases. Hanson works with federal and state health agencies to institute newborn screening options for children with SCID and other immune deficiency disorders in Texas and throughout the United States.

David Vetter’s mother, Carol Ann Demaret, said at the luncheons that she cannot express how much the care her son received at Texas Children’s Hospital means to her and her family.

“I am so grateful to Texas Children’s Hospital for giving my family 12 years with our son we never would have had otherwise,” she said. “I could work for the hospital for 100 years and still never repay them for that gift.”

April 12, 2016

The Baylor College of Medicine International Pediatric AIDS Initiative (BIPAI) and Texas Children’s Global Health have been helping meet the health care needs of mothers and babies across the globe for years. With global health programs and projects in more than 20 countries, BIPAI and Texas Children’s Global Health have developed a network of partners who are sometimes called on to respond to emergency situations. For these scenarios, we often turn to Medical Bridges, a Houston-based non-profit that provides medical supplies and equipment to support our work.

Recently, BIPAI and Texas Children’s Global Health addressed pediatric emergencies in Papua New Guinea and during the Ebola crisis, in Liberia, with the help of Medical Bridges. Presently, there is an outbreak of malaria among pediatric patients in Luanda, Angola.

To address this health emergency, BIPAI, Texas Children’s Global Health and Texas Children’s Pediatric Hematology & Oncology program have partnered with Medical Bridges, Chevron and SonAir, an Angolan national air services company, to provide drugs, supplies and equipment to the Hospital Pediatrico David Bernardino (Bernadino Pediatric Hospital) in Luanda and to the hospital in Cacuaco. These much-needed drugs and supplies will help the staff at the hospitals address the recent outbreak of malaria among the pediatric population.

“BIPAI and Texas Children’s Global Health are fortunate to have partners like Chevron and Medical Bridges that can mobilize and respond proactively to public health emergencies around the world,” said Michael Mizwa, leader of BIPAI and Texas Children’s Global Health.

Ali Moshiri, president of Chevron Africa and Latin America Exploration and Production Company, said the company is proud to be able to help mitigate public health situations such as these.

“We value our partnership with BIPAI and Texas Children’s Global Health,” Moshiri said. “This contribution underscores Chevron’s long-standing commitment to fight malaria and to the children of Angola who are most at risk for the disease”

The Baylor College of Medicine International Pediatric AIDS Initiative (BIPAI) and Texas Children’s Global Pediatric Hematology & Oncology program started an Angola Sickle Cell Initiative (ASCI) in 2011 with generous support from Chevron, aimed at bringing neonatal Sickle Cell Disease (SCD) screening and care to two regions in Angola: Luanda and Cabinda. To date, 135,000 babies have been screened and, in 2015, with a donation from Bristol-Myers Squibb (BMS), the first organized Hydroxyurea (HU) treatment program for Angola was begun.

April 8, 2016

The United States Agency for International Development (USAID) has awarded a $69.8 million grant to the Baylor College of Medicine Children’s Foundation–Malawi (Baylor–Malawi), an affiliate of the Baylor College of Medicine International Pediatrics AIDS Initiative at Texas Children’s Hospital, to support and expand HIV/AIDS programs in Southern Africa. The grant, through the USAID Regional HIV-AIDS Program, will fund a dynamic and innovative project called Technical Support to PEPFAR Programs in the Southern Africa Region, or TSP. Designed by the Baylor-Malawi team, TSP is a collaborative program that includes ICAP at Columbia University and Baylor College of Medicine Children’s Foundations in Botswana, Swaziland, Lesotho and Angola.

“While Southern Africa remains the epicenter of the HIV/AIDS epidemic, recent progress toward global elimination goals provides an impetus for coordinated, regional efforts,” said Dr. Saeed Ahmed, assistant professor of pediatrics with BIPAI who will lead TSP. “The program will address challenges related to HIV care and treatment, including pediatric and adolescent care, HIV prevention from mother to child and the unique gender aspects of the epidemic, providing a common regional platform for dissemination and rapid adoption of best practices.”

In support of the primary goal to reduce the impact of HIV/AIDS in Southern Africa, TSP objectives are to:
Improve clinical and other technical outcomes of partner programs in the region by providing mission programs with technical support and short- and medium-term program assistance and capacity building toward sustainability;

Improve and rapidly expand pediatric and adolescent treatment services in the region by providing technical assistance in the short and medium term and longterm program support;

Implement PEPFAR programs directly, in close cooperation with USAID.

The TSP will provide a wealth of technical expertise, Ahmed said, including human resource capacity, physical infrastructure, existing networking and program implementation experience, bringing together formally the unique and complementary strengths of the Baylor network and ICAP at Columbia University. The Baylor foundations are the leading providers of pediatric and adolescent HIV care and treatment in their respective countries with Centers of Excellence anchoring broad networks of satellite clinics. ICAP, the second-largest PEPFAR implementing program, offers incredible geographic scope and technical, programmatic and monitoring and evaluation expertise. Combined, the Baylor network and ICAP have managed more than $1 billion in funding over the past 5 years, and are implementing more than 50 U.S. Government supported initiatives.

To provide assistance to regional HIV/AIDS programs, Baylor-Malawi and its partners have organized a ‘Dream Team’ of experts who will provide the technical advising backbone of the program. Through its implementing partners, the Dream Team will have access to an extensive network of more than 1,500 people, including doctors, nurses, social workers, counselors, community health workers and volunteers, and pharmacists to provideHIV/AIDS program assistance and implementation.

“The high-quality assistance and program implementation provided by this project will strengthen the efforts in the region to achieve the UNAIDS 90-90-90 benchmarks, which call for 90 percent of HIV-infected individuals to know their status; 90 percent of patients who know their status to be started on and adherent to anti-retroviral therapy; and 90 percent of patients on ART to be viral suppressed by 2020” said Dr. Mark Kline, physician-in-chief, Texas Children’s Hospital and chairman of the department of pediatrics, Baylor College of Medicine.

Women and children are a special focus on the TSP program. It aims to achieve elimination of mother-to-child transmission, doubling of the number of children on anti-retroviral therapy and, through the DREAMS Initiative, assisting partners in developing interventions to address gender-based violence and reduce new HIV infections in adolescent girls and young women. DREAMS, or Determined, Resilient, AIDS-free, Mentored and Safe Women, is a PEPFAR program to reduce HIV infections among girls and young women in sub-Saharan Africa.

“This award is a true testament to the BIPAI Network’s ability and capacity as a global leader in pediatric HIV/AIDS and tuberculosis. Baylor–Malawi continues to excel in innovative program development,” said Michael Mizwa, chairman, Baylor–Malawi Board of Directors, chief operating office/senior vice president of BIPAI and director of global health at Texas Children’s Hospital.

“With the resources from this award, I am pleased that Baylor Malawi will lead a consortium that leverages the extensive expertise that is in the BIPAI network with its partners ICAP and regional ministries of health to accelerate the region’s advances to the 90-90-90 targets,” said Dr. Peter Kazembe, executive director of Baylor College of Medicine Children’s Foundation–Malawi.

March 1, 2016

Leaders with the Texas Children’s Special Isolation Unit recently hosted the first of what they plan to be regular educational conferences focusing on our advanced concepts of pediatric biocontainment.

Representatives from four children’s hospitals – the Ann & Robert H. Lurie’s Children’s Hospital of Chicago, Boston’s Children’s Hospital, Children’s Hospital of Colorado and the University of Texas-Houston – attended the two-day conference held February 25-26 at Texas Children’s Hospital West Campus.

Topics covered during the conference included staffing and clinical care of infectious patients, personal protective equipment (PPE) and procedures, and special isolation unit planning, development, policies and procedures. Conference attendees also participated in a PPE demonstration and discussion, and were given a tour of our newly opened Special Isolation Unit at West Campus.

“The conference was a wonderful opportunity for Texas Children’s to share our knowledge and experience with leaders from multiple organizations,” said Dr. Amy Arrington, medical director of the Special Isolation Unit. “We hope to continue this process for years to come in an effort to ensure all children affected by special pathogens are safely cared for in their time of need.”

Texas Children’s began working on its Special Isolation Unit more than a year ago, shortly after an unprecedented Ebola outbreak that resulted in the realization that we must be prepared to handle emerging infections as an institution. As a result, the state and the Centers for Disease Control and Prevention designated Texas Children’s Hospital as one of several pediatric Ebola treatment centers countrywide.

Texas Children’s Special Isolation Unit is the only one of its kind in Texas and the southwest region, and is among the few in the United States designated just for children. Located on the fifth floor of West Campus, the eight-bed unit is fully equipped to care for any infant or child with a serious communicable disease and has all of the measures available to assure safety of the health care team, other patients and their families.

Children coming to the special isolation unit will receive top notch care from a team of highly-trained nurses and doctors, led by Arrington, associate medical directors Dr. Gordon Schutze and Dr. Judith Campbell, and nursing leader, Sondra Morris.

Bench and Bedside is a digest of the previous month’s stories about the clinical and academic activities of our physicians and scientists. We welcome your submissions and feedback.

February 2

Texas Children’s, Rice University team up to develop new way to repair birth defect

Bioengineers at Texas Children’s Hospital and Rice University have won a National Institutes of Health grant to develop a new generation of patches to repair the damaged hearts of infants. The $1.9 million, 5-year grant will allow Jeffrey Jacot and his team to take the next steps in a long-running drive to improve the survival rates of such infants, many of whom are diagnosed in utero and require surgery soon after birth.

February 2

Department of State Health Services to award Texas Children’s $1 million grant for SIU

Texas Children’s is set to receive a $1 million grant from the Texas Department of State Health Services (DSHS) to put toward its newly constructed Special Isolation Unit at Texas Children’s Hospital West Campus. The funds, to be delivered during the next five years, will specifically go toward Ebola preparedness activities that bolster employee safety and quality of care.

February 2

Texas Children’s convenes task force, urges employees to educate themselves on Zika

In light of the multiple confirmed cases of Zika infection in Texas due to foreign travel, Texas Children’s leaders encourage employees, particularly pregnant women, to refrain from traveling to areas where the outbreak is growing and to follow precautionary measures to protect themselves from Zika exposure. Since the mosquito-carrying virus has been known to increase the risk of microcephaly, a neurological fetal birth defect, Texas Children’s recently convened a task force to develop management and research strategies based on screening criteria outlined by the Centers for Disease Control for pregnant women who may have been exposed to the Zika virus.

February 2 Kline: Children deserve access to best care

Many patients have been left scrambling to find a new medical home when a number of insurance companies decided not to provide in-network coverage for many hospitals in the Texas Medical Center, including Texas Children’s Hospital. Physician-in-Chief Dr. Mark W. Kline talks about how all children deserve access to the best care.

February 2

Zoghbi to receive medal for pioneering advancements in neuroscience research

Dr. Huda Zoghbi, director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s, will receive the 2016 Jessie Stevenson Kovalenko Medal from the National Academy of Science in April for her achievements in neuroscience, which includes unlocking the genetic and molecular mysteries behind rare neurological disorders.

February 2

Clinical Research Center presents research award to Dr. Anvari

The Clinical Research Center will present the Clinical Research Award for First Quarter 2016 to Dr. Sara Anvari, physician, Allergy and Immunology. Dr. Anvari is a dedicated clinical scientist for the food allergy research trials at Texas Children’s Hospital.

February 9

Three NRI researchers recognized for their contributions to neuroscience research

Drs. Michael Wangler and Shinya Yamamoto recently obtained a research grant from the Simon’s Foundation for Autism Research Initiative (SFARI) to advance their study on autism spectrum disorders. Their study titled, “In vivo functional analysis of autism candidate genes” is one of five projects selected for research funding by the SFARI. Dr. Andrea Ballabio, founder and director of the Telethon Institute of Genetics and Medicine (TIGEM), Italy, professor at Baylor and faculty member at the NRI, has been selected to receive the 2016 Louis-Jeantet Prize for Medicine. He will share this award with biochemist John Diffley, associate research director at the Francis Crick Institute, United Kingdom.

February 16

Study finds premature infants benefit from exclusive human milk-based diet

A recent Baylor College of Medicine study led by Texas Children’s neonatologist Dr. Amy Hair, and published in the journal Breastfeeding Medicine, found that premature infants weighing less than 1,250 grams at birth showed improved outcomes after being fed a human milk-based diet.

February 16

Mata twins celebrate one-year anniversary after historic separation

A year after being separated in a marathon surgery at Texas Children’s Hospital, formerly conjoined twins Knatalye and Adeline Mata are healthy, lively toddlers. Several members of our medical staff involved in the girls’ care got to see how much they have grown and how far they have come during a recent visit to Texas Children’s for their follow-up appointments with pediatric subspecialists monitoring their health and development. Hear some of their reactions and see for yourself how much the girls have progressed.

February 16

Heart Center launches series of educational animated videos

Featuring an armadillo, a bison and robot-like caregivers called Blings, a series of animated videos created by Texas Children’s Heart Center aims to help educate patients and their families about various heart conditions and treatment options. Six of the videos were unveiled at a February 15 red carpet premier and can be accessed on the Texas Children’s website at http://www.texaschildrens.org/hearteducation.

February 23

CVICU physician performs CPR, saves man’s life during spin class

When Dr. Natasha Afonso clipped in to a bike for a spin class on a recent Thursday evening, she didn’t know the skills she uses each day to treat patients in the CVICU would mean the difference between life and death for a fellow rider. Toward the end of the 45-minute, high-intensity class, Afonso heard 50-year-old Scott Corron collapse and fall off his bicycle. Because he wasn’t breathing and had no pulse, Afonso immediately started CPR, an action that ultimately saved Corron’s life.

February 23

New in situ simulation program enhances role clarity in high-risk emergencies

Texas Children’s Simulation Center recently launched the first-ever Neonatal Comprehensive In Situ Simulation Program for NICU providers at the Pavilion for Women. The program focuses on improving crisis resource management skills, one of which is role clarity, to ensure all code team members know each other’s specific roles when delivering care to patients during high-risk medical emergencies.

February 23

Texas Children’s helps develop nation’s first hospital-based rapid test for the Zika virus

Pathologists and clinical laboratory scientists at Texas Children’s Hospital and Houston Methodist Hospital developed the nation’s first hospital-based rapid test for the Zika virus in a matter of weeks as part of the L.E. and Virginia Simmons Collaborative in Virus Detection and Surveillance. Pathologist-in-Chief Dr. James Versalovic and Dr. James Dunn, director of medical microbiology and virology, led Texas Children’s Zika test development team. The new diagnostic test identifies virus-specific RNA sequences to detect the virus and can distinguish Zika virus from other virus infections like Dengue, West Nile or Chikunguny.

February 23

Blaney receives Pioneer Award for contributions in pediatric neuro-oncology The Children’s Brain Tumor Foundation honored Dr. Susan Blaney with the Pioneer Award for Pediatric Neuro-Oncology, celebrating her 25 years of dedication to the search for new and better treatments for children with brain and spinal cord tumors. Blaney’s extensive experience in clinical translational research focuses on developing new treatment strategies for children with brain tumors and other refractory cancers. Blaney has been instrumental in developing more new agent clinical trials than anyone in the field of pediatric oncology.

February 23

Dietrich voted president-elect of North American Society for Pediatric and Adolescent Gynecology

Chief of Pediatric and Adolescent Gynecology Dr. Jennifer Dietrich has been voted president-elect of the North American Society for Pediatric and Adolescent Gynecology. Her tenure as president-elect begins in April. She will be voted in as president in April 2017.

February 23

Texas Children’s Health Plan Center for Children and Women earns accolades for CenteringPregnancy® program Texas Children’s Health Plan’s Center for Children and Women has earned site approval for its CenteringPregnancy® program. The Centering Healthcare Institute (CHI) has awarded both the Southwest and Greenspoint locations the official designation for closely following the CenteringPregnancy® model.

February 23, 2016

Pathologists and clinical laboratory scientists at Texas Children’s and Houston Methodist Hospital developed the nation’s first hospital-based rapid test for the Zika virus in a matter of weeks as part of the L.E. and Virginia Simmons Collaborative in Virus Detection and Surveillance.

This collaborative program was established to facilitate rapid development of tests for virus detection in a large metropolitan area. These tests are customized to each hospital’s diagnostic laboratory and designed to provide results within several hours. Before the Zika test was developed, physicians faced the possibility of long delays of testing in local and state public health laboratories and the Centers for Disease Control (CDC).

Texas Children’s Pathologist-in-Chief Dr. James Versalovic and Dr. James Dunn, director of medical microbiology and virology, led Texas Children’s team tasked with developing a rapid test for Zika virus.

Transmitted primarily through mosquito bites, Zika is a flavivirus that contains RNA as its genetic material. This new diagnostic test identifies virus-specific RNA sequences to detect Zika virus and can distinguish Zika virus from other virus infections like Dengue, West Nile or Chikungunya. Every viral particle contains genes in its RNA and these RNA sequences are directly detected on blood, amniotic fluid, urine and spinal fluid.

Currently, only registered patients at Texas Children’s or Houston Methodist hospitals can receive the test but the labs will consider referral testing from other hospitals and clinics in the future.

The test will be initially offered to patients with a positive travel history and symptoms consistent with acute Zika virus infection such as a rash, arthralgias or fever, or asymptomatic pregnant women with a positive travel history to any of the affected countries. The World Health Organization has advised pregnant women to consult their doctors before traveling to places with Zika virus outbreaks and consider delaying travel. The CDC issued similar guidelines to pregnant women last month.

“With travel-related cases of the Zika virus becoming more prevalent in the U.S. coupled with the looming increase in mosquito exposure during spring and summer months, we must be prepared for a surge of Zika testing demand,” Versalovic said. “We must provide answers for anxious mothers-to-be and families who may experience signs and symptoms or may simply have a travel history to these endemic areas.”

Click here for more information about the Zika virus and what Texas Children’s maternal fetal task force is doing to develop strategies based on CDC screening guidelines for pregnant women who may have been exposed to the Zika virus.

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